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HYPOXIA-INDUCIBLE FACTORS AND CANCER PROGRESSION.

TITLE OF TALK

 
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DR. GREGG SEMENZA M.D., PH.D.

2019 NOBEL LAUREATE IN PHYSIOLOGY AND MEDICINE

Professor of Genetic Medicine, Biological Chemistry, Oncology, Pediatrics, Radiation Oncology and Molecular Radiation Sciences.

Director of Vascular Program at The Institute for Cell Engineering.

Johns Hopkins University School of Medicine

Dr. Semenza is professor of genetic medicine, with joint appointments in pediatrics, radiation oncology, biological chemistry, medicine and oncology, at the Johns Hopkins University School of Medicine. He serves as director of the Vascular Program at the Johns Hopkins Institute for Cell Engineering.

Dr. Semenza’s lab made the paradigm shifting discovery of hypoxia-inducible factor 1 (HIF-1), which is a transcription factor that controls the expression of thousands of genes in response to changes in oxygen availability in virtually all metazoan species. The finding, for which he received the 2019 Nobel Prize in Physiology or Medicine, has far-reaching implications for understanding and treating many common diseases, including anemia, ischemic cardiovascular disease, chronic lung diseases, and cancer.

Dr. Semenza received his bachelor’s degree from Harvard University and his medical degree and doctorate (in genetics) from the University of Pennsylvania. He completed pediatrics residency training at Duke University Medical Center and postdoctoral training in medical genetics at Johns Hopkins. He joined the Johns Hopkins faculty in 1990.

Dr. Semenza’s current research interests include investigating the molecular mechanisms of oxygen homeostasis, the role of HIF-1 in cancer progression, and the development of novel HIF inhibitors for the treatment of cancer and blinding eye diseases. He has authored more than 450 research articles and book chapters, and his work has been cited by other scientists more than 160,000 times.

Dr. Semenza is a founding fellow of the American College of Medical Genetics and Genomics, and was elected to the Association of American Physicians and the National Academy of Sciences in 2008, and the National Academy of Medicine in 2012. He serves as deputy editor of The Journal of Clinical Investigation. He has been honored as a Fellow of the Society for Redox Biology and Medicine (2017), Distinguished Scientist of the American Heart Society (2020) and a Fellow of the AACR Academy (2020).

In addition to the Nobel Prize, Dr. Semenza has received numerous other awards, including the Albert Lasker Basic Medical Research Award (2016), Wiley Prize in Biomedical Sciences (2014), Lefoulon-Delalande Grand Prize from the Institut de France (2012), and Canada Gairdner International Award (2010).